C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/47 (2006.01) C07C 235/16 (2006.01) C07C 235/24 (2006.01) C07C 235/38 (2006.01) C07D 213/64 (2006.01) C07D 215/26 (2006.01) C07D 215/38 (2006.01) C07D 215/40 (2006.01) C07D 215/48 (2006.01) C07D 307/54 (2006.01) C07D 401/12 (2006.01) C07D 405/04 (2006.01) C07D 405/06 (2006.01)
Patent
CA 2255333
The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation: General Formula (I) Image (wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)]. Image [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].
Abe Masayoshi
Misumi Osamu
Sakai Mitsuru
Takagaki Hidetsugu
Yamaguchi Shinobu
Activus Pharma Co. Ltd.
Dainippon Ink And Chemicals Inc.
Marks & Clerk
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