Quinolizidinone m1 receptor positive allosteric modulators

Details Quinolizidinone m1 receptor positive allosteric modulators Quinolizidinone m1 receptor positive allosteric modulators

C - Chemistry, Metallurgy

07

D

C07D 455/02 (2006.01) A61K 31/4375 (2006.01) A61K 31/4725 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2716921

The present invention is directed to compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

La présente invention se rapporte à des composés de formule (I) qui sont des modulateurs allostériques positifs du récepteur M1, et qui sont utiles dans le traitement de maladies dans lesquelles est impliqué le récepteur M1, comme la maladie d'Alzheimer, la schizophrénie, les troubles du sommeil ou de la douleur. L'invention se rapporte également à des compositions pharmaceutiques qui comprennent les composés, et à l'utilisation des composés et des compositions dans le traitement de maladies influencées par le récepteur M1.

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