C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 455/02 (2006.01) A61K 31/4375 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2700648
The present invention is directed to spiropiperidine compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
La présente invention porte sur les composés de spiropipéridine de la formule (I) qui sont des modulateurs allostériques positifs du récepteur M1 et qui s'utilisent dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué, telles que la maladie d'Alzheimer, la schizophrénie, la douleur ou des troubles du sommeil. L'invention porte également sur des compositions pharmaceutiques comportant les composés et sur l'utilisation des composés et des compositions dans le traitement de maladies à médiation par le récepteur M1.
Chang Ronald K.
Kuduk Scott D.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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