C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 9/10 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2634168
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
La présente invention concerne de nouveaux composés à base de quinolone qui présentent une activité inhibitrice de prolyle hydroxylase. Cette invention concerne en outre des procédés d'augmentation des taux ou de l'activité de HIF chez un sujet ou de traitement d'un état associé aux taux ou à l'activité de HIF chez un sujet par administration au sujet d'au moins un composé à base de quinolone. Cette invention met en AEuvre en outre des essais pour la détection d'un résidu hydroxyproline dans une molécule de HIF.
Allen Jennifer R.
Biswas Kaustav
Burli Roland
Dao Jennifer
Frohn Michael J.
Amgen Inc.
Gowling Lafleur Henderson Llp
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