C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/55 (2006.01) C07D 215/56 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2065846
A quinolone carboxylic acid derivative having the following formula (1), (See formula I) wherein R1 is a hydrogen atom, an alkyl group, an aralkyl group, or an ester residual group which can be hydrolyzed in living bodies, R2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH2, O, S, SO, SO2, or N-R3, wherein R3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatment and prevention of various infectious diseases in clinics.
Asaoka Takemitsu
Kawahara Ryuichi
Konno Fujiko
Kuraishi Tadayuki
Matsuda Hideaki
Bausch & Lomb Incorporated
Osler Hoskin & Harcourt Llp
Ss Pharmaceutical Co. Ltd.
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