Quinolone compound and pharmaceutical composition

Details Quinolone compound and pharmaceutical composition Quinolone compound and pharmaceutical composition

C - Chemistry, Metallurgy

07

D

C07D 215/22 (2006.01) A61K 31/4741 (2006.01) A61K 31/4745 (2006.01) A61K 31/506 (2006.01) C07D 215/28 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 407/04 (2006.01) C07D 407/12 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01) C07D 493/04 (2006.01)

Patent

CA 2745019

The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein: R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 represents substituted or unsubstituted phenyl or the like; R4 represents halogen or the like; R5 represents hydrogen or the like; R6 represents hydrogen or the like; and R7 represents hydrogen or the like.

La présente invention concerne un composé de quinolone qui inhibe la progression chronique du parkinson ou protège les neurones dopaminergiques contre l'étiologie pathologique, et donc inhibe la progression d'une dysfonction du système nerveux, de façon à retarder l'administration de L-dopa, tout en améliorant la fonction neuronale. Le composé de quinolone de la présente invention est représenté par la formule (1) dans laquelle R1 est hydrogène ou analogue; R2 est hydrogène ou analogue; R3 est phényle éventuellement substitué, ou analogue; R4 est halogène ou analogue; R5 est hydrogène ou analogue; R6 est hydrogène ou analogue; et R7 est hydrogène ou analogue.

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