Quinolone compound and pharmaceutical composition

Details Quinolone compound and pharmaceutical composition Quinolone compound and pharmaceutical composition

C - Chemistry, Metallurgy

07

D

C07D 215/28 (2006.01) A61K 31/47 (2006.01) A61P 25/00 (2006.01) C07D 215/40 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2688448

The present invention provides a quinolone compound represented by General Formula (1) or a salt thereof, wherein R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, etc.; R3 represents a phenyl group optionally being substituted with one or more substituents, etc.; R4 represents a halogen atom; R5 represents a hydrogen atom or halogen atom; R6 represents a hydrogen atom; and R7 represents a hydroxyl group, etc. The quinolone compound have a functional improvement effect, which suppresses progression of neurological dysfunction by inhibiting the chronic progression of Parkinson's disease or protecting dopamine neurons from the disease etiology, thereby prolonging the period before first administration begins.

La présente invention concerne un composé de quinolone de formule générale (I) ou son sel. Dans ladite formule, R1 est un atome d'hydrogène, etc.; R2 est un atome d'hydrogène, etc.; R3 est un groupe phényle éventuellement substitué par un ou plusieurs substituants, etc.; R4 est un atome d'halogène; R5 est un atome d'hydrogène ou un atome d'halogène; R6 est un atome d'hydrogène; et R7 est un groupe hydroxyle, etc. Le composé de quinolone de l'invention présente un efffet d'amélioration fonctionnelle qui arrête l'évolution d'un dysfunctionnement neurologique en inhibant l'évolution chronique de la maladie de Parkinson ou en protégeant les neurones dopaminergiques de l'étiologie de la maladie, ce qui prolonge la période précédant le début de la première administration.

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