C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 31/47 (2006.01) C07D 215/233 (2006.01) C07D 405/06 (2006.01) C12P 17/12 (2006.01)
Patent
CA 2229785
This invention provides processes for producing quinolone compounds which comprise cultivating Amycolata sp. FERM BP-4785, and then isolating quinolone compounds from the fermentation broth. The compounds produced by these processes include compounds of formula (I) wherein R1 is H, R2 is (a) and R3 is CH3; R1 is CH3, R2 is (a) and R3 is CH3; or R1 is CH3, R2 is (b) and R3 is CH3; and the like. The present invention also relates to a pharmaceutical composition comprising the same, which is useful in the treatment of diseases, disorders and adverse conditions caused by Helicobacter pylori and is particularly useful in the treatment of gastroduodenal disorders, diseases and adverse conditions caused thereby.
Cette invention se rapporte à des procédés de production de composés de quinolone, ces procédés consistant à cultiver Amycolata sp. FERM BP-4785, puis à isoler les composés de quinolone du bouillon de fermentation. Les composés obtenus par ces procédés sont les composés de la formule (I) dans laquelle R?1¿ représente H, R?2¿ représente la formule (a) et R?3¿ représente CH¿3?; R?1¿ représente CH¿3?, R?2¿ représente la formule (a) et R?3¿ représente CH¿3?; ou R?1¿ représente CH¿3? et autre. La présente invention se rapporte également à une composition pharmaceutique comprenant ces composés et qui est utile dans le traitement de maladies, troubles et états indésirables provoqués par Hélicobacter pylori et notamment dans le traitement de troubles gastro-duodénaux.
Dekker Koenraad A.
Huang Liang H.
Inagaki Taisuke
Kojima Nakao
Kojima Yasuhiro
Pfizer Inc.
Smart & Biggar
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