Quinolone derivatives and their use as pharmaceuticals

Details Quinolone derivatives and their use as pharmaceuticals Quinolone derivatives and their use as pharmaceuticals

C - Chemistry, Metallurgy

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D

260/281.5

C07D 215/22 (2006.01) C07D 215/233 (2006.01) C07D 215/26 (2006.01) C07D 215/36 (2006.01) C07D 215/56 (2006.01)

Patent

CA 1173445

G.1182 QUINOLONE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS ABSTRACT OF THE INVENTION Compounds of the following formula are described: Image (I) in which n is 0, 1 or 2, R1 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl, trifluoromethyl, halo or nitro, and R2 and R3 are each independently hydrogen or C1-4 alkyl, and salts thereof. The compounds are useful in the treatment of immediate hypersensitivity conditions and are prepared by reaction of the appropriate formylquinolone with malonic acid, ylid or phosphonate.

392629

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