C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/22 (2006.01) A61K 31/407 (2006.01) A61P 25/16 (2006.01)
Patent
CA 2631917
The present invention is directed to quinolone compounds of general formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, pain or sleep disorders, and to novel M1 receptor positive allosteric modulator compounds of formulae (II) to (VIII). The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases in which the M1 receptor is involved.
La présente invention concerne des composés de quinolone de formule générale (I) qui sont des modulateurs allostériques positifs de récepteur M1 et qui sont utiles dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué, telles que la maladie d'Alzheimer, la douleur ou les troubles du sommeil, et de nouveaux composés modulateurs allostériques positifs de récepteur M1 de formules (II) à (VIII). L'invention concerne en outre des compositions pharmaceutiques comprenant les composés, et l'utilisation des composés et compositions dans le traitement de maladies dans lesquelles le récepteur M1 est impliqué.
Hallett David
Lindsley Craig
Shipe William D.
Merck & Co. Inc.
Merck Sharp & Dohme Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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