C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/179, 260/295
C07C 50/00 (2006.01) C07C 45/29 (2006.01) C07C 46/00 (2006.01) C07C 46/02 (2006.01) C07C 46/06 (2006.01) C07C 47/277 (2006.01) C07C 50/06 (2006.01) C07C 50/08 (2006.01) C07C 50/28 (2006.01) C07C 50/30 (2006.01) C07C 50/32 (2006.01) C07C 59/82 (2006.01) C07C 66/00 (2006.01) C07C 69/95 (2006.01) C07D 333/22 (2006.01) C07D 333/24 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1285280
24205-632 ABSTRACT OF THE DISCLOSURE Quinone derivatives of the general formula: Image (I) (wherein R1 and R2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R1 and R2 combine with each other to represent -CH=CH-CH=CH-; R3 is a hydrogen atom or a methyl group; R4 is an aliphatic, aromatic or heterocyclic group which may be substituted; R5 is a methyl or methoxy group, a hydroxymethyl group which may be susbtituted or a carboxyl group which may be esterified or amidated; Z is a group represented by -C?C-, -CH=CH-, Image , Image , Image , Image or Image ; n is an integer of 0 to 10; m is an integer of 0 to 3; k is an integer of 0 to 5, provided, however, that in the case of m being 2 or 3, Z and k can vary arbitrarily within the bracketed repeating units) are novel compounds, possess metabolism ameliorating action for polyunsaturated fatty acids, particularly production inhibitory activity of lipid peroxides (antioxidant activity) or production inhibitory activity of 5-lipoxygenase metabolites in mammals, and of use as drugs, such as antiasthmatic, antiallergic agent and cerebral-circulatory metabolism ameliorating agent.
487926
Maki Yoshitaka
Terao Shinji
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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