Quinone prodrug compositions and methods of use

Details Quinone prodrug compositions and methods of use Quinone prodrug compositions and methods of use

A - Human Necessities

61

K

A61K 31/353 (2006.01) A61K 31/337 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07D 311/92 (2006.01)

Patent

CA 2583700

The present invention relates to quinone prodrug compositions and therapeutic methods using such prodrug compositions. Preferably, the quinone compounds of the invention are napthoquinone compounds such as .beta.-lapachone or .beta.- lapachone analogs. The quinone prodrug compositions of the invention exhibit improved solubility, stability, bioavailability, and pharmacokinetic properties, as well as improved plasma half-life in vivo.

La présente invention concerne des compositions de promédicaments à base de quinone et leurs méthodes d'utilisation à des fins thérapeutiques. Les composés quinone de l'invention sont de préférence des composés de napthoquinone tels que le ß-lapachone ou des analogues du ß-lapachone. Les compositions de promédicaments à base de quinone de l'invention marquent une amélioration en termes de solubilité, de stabilité, de biodisponibilité ainsi que de demi-vie plasmatique <i>in vivo</i>.

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