C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/26 (2006.01) C12Q 1/32 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2460317
The present invention relates, in general, to quinone reductase 2 (QR2) and aldehyde dehydrogenase (ALDH), and, in particular, to methods of screening compounds for their ability to modulate the activity of QR2 and/or ALDH and thereby to function as anti-malarial, anti-arthritic and/or anti-lupus agents. The invention further relates to the use of compounds that inhibit ALDH in the production of stem cells en masse.
La présente invention concerne, d'une manière générale, la quinone réductase 2 (QR2) et l'aldéhyde déshydrogénase (ALDH) et notamment des procédés pour cribler des composés afin de vérifier leur capacité de moduler l'activité de QR2 et/ou d'ALDH et de fonctionner en tant qu'agent antipaludique, antiarthritique et/ou dirigé contre le lupus. L'invention concerne aussi l'utilisation des composés qui inhibent l'ALDH dans la production en masse de cellules souches.
Duke University
Goudreau Gage Dubuc
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