C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/246, 260/265
C07D 241/52 (2006.01) A23K 1/16 (2006.01) A23K 1/17 (2006.01) C07D 403/02 (2006.01)
Patent
CA 1184913
ABSTRACT OF THE DISCLOSURE The invention relates to new quinoxaline-1,4-derivatives of the general formula (I) and biologically acceptable salts thereof, Image (I) wherein Q is a hydrogen atom or a methyl group, R1 represents a hydrogen atom, a cyano, lower alkanoyl or nitro group or a halogen atom, R2 stands for cyano, lower alkanoyl, or a group of the general formula -COOR3, -CONR4R5 or -CO-NH-NR4R5, and R3 represents a hydrogen atom or a C1-18 alkyl, C6-12 aryl or C6-10 aryl-C1-4 alkyl) group optionally substituted by a halogen atom or a hydroxy group, whereby the aromatic ring of the said groups may optionally contain 1-3 identical or different substituents selected from the group consisting of lower alkyl or alkoxy, amino, nitro, halogen and/or hydroxy, R4 is hydrogen or optionally halo or hydroxy substituted C1-18 alkyl and R5 is hydrogen, optionally halo or hydroxy substituted C1-8 alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, C6-10 aryl or C6-10 aryl-(C1-4 alkyl) - whereby the aryl ring of the said two latter groups may optionally contain 1-3 identical or different substituents selected from the group consisting of lower alkoxy, lower alkyl, amino, nitro, halo and/or hydroxy substituents -; or lower alkoxycarbonyl, lower alkylsulfonyl or C6-10 arylsulfonyl optionally substituted by amino or lower alkyl; or a mono- or bicyclic heteroarylsulfonyl group; or R4 and R5 represent, together with the adjacent nitrogen atom, a 5 or 6 membered heterocyclic group optionally substituted by a further nitrogen or oxygen atom, with the proviso that if Q represents hydrogen and R2 stands for carboxy, R1 may denote only other than hydrogen. Moreover, the invention relates to a process for the preparation of the above compounds and fodder concentrates, fodder additives or fodders containing the said compounds. The new compounds of the general formula (I) possess weight-gain increasing and antibacterial effects and can be used to advantage in the animal husbandry.
378085
Benko Pal
Bozsing Daniel
Gundel Janos
Magyar Karoly
Egyt Gyogyszervegyeszeti Gyar
Fetherstonhaugh & Co.
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