Quinoxaline compounds and their preparation and use

Details Quinoxaline compounds and their preparation and use Quinoxaline compounds and their preparation and use

C - Chemistry, Metallurgy

07

D

167/217, 260/265

C07D 241/44 (2006.01) A61K 31/495 (2006.01) C07D 241/52 (2006.01)

Patent

CA 2004078

ABSTRACT Heterocyclic dihydroxyquinoxaline compounds having the formula Image wherein R1 is hydroxy, alkoxy, aryloxy, aralkyloxy, cycloalkylalkoxy, cycloalkoxy, or acyloxy; and R5, R6, R7 and R8 independently are hydrogen, NO2, halogen, CN, SO2NR'R', SO2R', CF3, or OR', wherein R' is hydrogen or C1-4-alkyl; The invention also relates to a method of preparing the compounds, pharmaceutical compositions thereof, and their use. The compounds are useful in the treatment of indications caused by hyperactivity of the excitatory neurotransmitters, particularly the quisqualate receptors, and especially as neuroleptics.

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