Quinoxaline derivatives with affinity for quisqualate-receptors

Details Quinoxaline derivatives with affinity for quisqualate-receptors Quinoxaline derivatives with affinity for quisqualate-receptors

C - Chemistry, Metallurgy

07

D

C07D 241/44 (2006.01) A61K 31/155 (2006.01) A61K 31/33 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07F 9/547 (2006.01) C07F 9/6509 (2006.01)

Patent

CA 2099270

ABSTRACT OF THE DISCLOSURE Quinoxaline derivatives have the formula (I), in which R1 is C1-12-alkyl substituted by R2, C2-12-alkenyl substituted by R2, C2-12-alkinyl substituted by R2,C3-7- cycloalkyl substituted by R2, -(CH2)n-C6-12-aryl substituted by R2 in the aryl or alkyl residue or -(CH2)n-hetaryl substituted by R2 in the hetaryl or alkyl residue; R4 is hydrogen, C1-12 alkyl substituted by R2, C2-12-alkenyl substituted by R2, C2-12-alkinyl substituted by R2, (CH2)n- C6-12-aryl substituted by R2 in the aryl or alkyl residue, or -(CH2)n-hetaryl substituted by R2 in the hetaryl or alkyl residue; R5, R6, R7 and R8 are the same or different and represent hydrogen, halogen, nitro, NR9R10, NHCOR11, SO2R12, C3-7-cycloalkyloxy, COR13, cyano, CF3, C1-6-alkyl, C1-4- alkoxy or imidazole possibly substituted by cyano, C1-4-alkyl or -COO-C1-6-alkyl or R5 and R6 or R7 and R8 represent a condensated benzene ring, and R2 stands for -C)-R3, or -PO-XY and is present once or twice in the same or a different form. Also disclosed are the preparation of thess derivatives and their use in medicaments.

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