Quinoxaline dihydrohalide dihydrates and synthetic methods...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 403/12 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2601978

Crystalline polymorph forms of Gonadotropin Releasing Hormone receptor antagonists, including crystalline polymorphs of quinoxaline dihydrohalide dihydrates, in particular crystalline polymorphs of 6-({4-[2-(4-tert- butylphenyl)-lH-benzimidazol-4-yl]-piperazin-l- yl}methyl)-quinoxaline dihydrochloride dihydrate, methods of making the same, as well as pharmaceutical compositions, and dosage forms containing them are disclosed.

L~invention décrit des formes cristallines polymorphes d~antagonistes du récepteur de l~hormone de libération de la gonadotrophine, incluant des polymorphes cristallins de dihydrates de dihalogénures de quinoxaline, en particulier des polymorphes cristallins du dihydrate de dihydrochlorure de 6-({4-[2-(4-tert-butylphényl)-1H-benzimidazol-4-yl]pipérazin-1-yl}méthyl)quinoxaline, leurs méthodes de préparation, ainsi que les compositions pharmaceutiques et les formes posologiques les contenant.

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