Quinoxalines as b raf inhibitors

Details Quinoxalines as b raf inhibitors Quinoxalines as b raf inhibitors

C - Chemistry, Metallurgy

07

D

C07D 241/40 (2006.01) A61K 31/498 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2583096

The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

L'invention concerne des composés chimiques de formule (I) ou des sels acceptables pharmaceutiquement correspondants qui possèdent une activité inhibitrice B-Raf et sont utilisés, par conséquent, pour leur activité anticancéreuse et dans des méthodes de traitement d'un être humain ou d'un corps animal. Cette invention a aussi pour objet des processus de fabrication desdits composés chimiques, des compositions pharmaceutiques les renfermant et leur utilisation dans la fabrication de médicaments utilisés dans la production d'un effet anticancéreux chez un animal à sang chaud, tel que l'homme.

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