C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 241/44 (2006.01) A61K 31/498 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2520839
The invention relates to quinoxalinone derivatives of general Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.General Formula (I) wherein X and R1-R9 are as defined in the description
La présente invention concerne des dérivés de quinoxalinone représentés par la formule générale (I) et l'utilisation de ceux-ci dans la préparation de compositions pharmaceutiques. Cette invention concerne aussi des aspects liés, notamment des processus de préparation de ces composés, de compositions pharmaceutiques contenant un ou plusieurs de ces composés et, plus particulièrement l'utilisation de ces composés comme antagonistes du récepteur d'orexine. Dans la formule générale (I) X et R?1¿-R?9¿ sont tels que définis dans les descriptions.
Aissaoui Hamed
Clozel Martine
Koberstein Ralf
Sifferlen Thierry
Weller Thomas
Actelion Pharmaceuticals Ltd
Gowling Lafleur Henderson Llp
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