Quinoxalinyl derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 487/04 (2006.01) A61K 31/498 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2708042

The present invention relates to compounds of Formula (I) or (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.

L'invention concerne des composés de formule (I) ou (II), ou des sels, esters ou promédicaments pharmaceutiquement acceptables de ceux-ci qui inhibent l'activité de sérine protéase, en particulier l'activité de la de la protéase NS3-NS4A du virus de l'hépatite C (HCV). Par conséquent, les composés de la présente invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont utiles comme agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés précités pour une administration à un sujet souffrant d'une infection par le HCV. L'invention concerne également des procédés de traitement d'une infection par le HCV chez un sujet par administration d'une composition pharmaceutique comprenant un composé de la présente invention.

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