Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors

Details Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors Quinoxalinyl macrocyclic hepatitis c serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 38/55 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2522561

The present invention relates to compounds of Formula (I) or (II), or a pharmaceutically acceptable salt, ester, or prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

La présente invention concerne des composés représentés par la formule (I) ou (II), ou un sel, un ester, ou un promédicament acceptables d'un point de vue pharmaceutique de ceux-ci, inhibant l'activité des sérine protéases, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Les composés de l'invention interviennent par conséquent dans le cycle de vie du virus de l'hépatite C, et sont également utilisés comme agents antiviraux. La présente invention concerne également des compositions pharmaceutiques contenant lesdits composés, destinées à être administrées à un sujet souffrant d'une infection à VHC. L'invention concerne enfin des méthodes de traitement d'une infection à VHC chez un sujet par administration d'une composition pharmaceutique contenant les composés de la présente invention.

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