Quinoxalinyl macrocyclic hepatitis c virus serine protease...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 409/14 (2006.01) A61K 31/495 (2006.01) A61P 31/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 475/00 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2654945

The present invention relates to compounds, including compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof, which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

La présente invention concerne des composés, dont des composés de formule (I), ou un sel, ester ou promédicament acceptable du point de vue pharmaceutique de ceux-ci, lesquels inhibent l'activité des protéases à sérine, en particulier l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). En conséquence, les composés de la présente invention interfèrent avec le cycle biologique du virus de l'hépatite C et sont également utiles en tant qu'agents antiviraux. La présente invention concerne en outre des compositions pharmaceutiques comprenant les composés susmentionnés pour l'administration à un sujet souffrant d'une infection à VHC. L'invention concerne également des procédés de traitement d'une infection à VHC chez un sujet en administrant une composition pharmaceutique comprenant les composés de la présente invention.

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