Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives...

C - Chemistry – Metallurgy – 07 – D

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C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2701126

The present invention relates to compounds and formulations capable of affecting nicotinic acetylcholine receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the alpha7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.

L'invention concerne des composés et des formulations aptes à affecter des récepteurs nicotiniques d'acétylcholine (nAChRs), par exemple en tant que modulateurs de sous-types spécifiques de récepteur nicotinique (spécifiquement, le sous-type de nAChR alpha7). La présente invention concerne également des procédés de traitement d'une large variété d'états et de troubles, en particulier ceux associés au dysfonctionnement des systèmes nerveux centraux et autonomes.

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