Quinuclidine and azabicyclo¬2.2.1|heptane pyrazinyl ethers...

Details Quinuclidine and azabicyclo¬2.2.1|heptane pyrazinyl ethers... Quinuclidine and azabicyclo¬2.2.1|heptane pyrazinyl ethers...

C - Chemistry, Metallurgy

07

D

C07D 471/08 (2006.01) A61K 31/495 (2006.01) C07D 453/02 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2165751

The compound of the formula: Image in which Y is oxygen or sulfur; A is oxygen, sulfur or -NR2, where R2 is hydrogen or alkyl; R is ethyl, propyl, isopropyl, isobutyl, 2,2,2-trifluoroethyl, 3,3,3-trifluoro- propyl, 1-trifluoromethyl-2,2,2-trifluoroethyl, 2-trifluoromethyl-3,3,3-trifluoropropyl, cyclopropyl, cyclopropylmethyl, cyclopropylethyl, cyclobutyl, cyclobutylmethyl, cyclopentyl, cyclopentylmethyl, cyclohexyl, cyclohexylmethyl, thienyl, thienylmethyl, phenyl or benzyl; and n is one of the integers 1 or 2; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.

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