Quinuclidine carbamate derivatives and their use as m3...

Details Quinuclidine carbamate derivatives and their use as m3... Quinuclidine carbamate derivatives and their use as m3...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 43/00 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 471/08 (2006.01)

Patent

CA 2441896

A compound which is a carbamate of formula (I), wherein R1 represents (a), (b), (c), (d), (e), (f), (g), (h) or (i); R2 represents a benzyl, phenethyl, furan-2-ylmethyl, furan-3-ylmethyl, thiophen-2-ylmethyl or thiophen-3-ylmethyl group or a straight or branched alkyl group having 3 or 8 carbon atoms, an alkenyl group having 3 to 8 carbons atoms, or a cycloalkyl group of 3 to 6 carbon atoms; p is 1 or 2 and the substitution in the azoniabicyclic ring may be in the 2, 3 or 4 position including all possible configurations of the asymmetric carbons; or a pharmaceutically acceptable salt thereof. The pharmaceutically acceptable salt may be of formula (II).

L'invention concerne un composant qui est un carbamate de formule (I), dans laquelle R1 repr~sente (a), (b), (c), (d), (e), (f), (g), (h) ou (i); R2 repr~sente un benzyl, ph~n~thyl, furan-2-ylm~thyl, furan-3-ylme~thyl, thiophen-2-ylm~thyl ou un groupe thiophen-3-ylm~thyl ou un groupe alkyle ramifi~ ou droit poss~dant de 3 ~ 8 atomes de carbone, un groupe alk~nyle poss~dant de 3 ~ 8 atomes de carbone ou un groupe cycloalkyle de 3 ~ 6 atomes de carbone; p est ~gal ~ 1 ou 2 et la substitution dans le cycle azoniabicyclique peut Útre en position 2, 3 ou 4 incluant toutes les configurations possibles de carbones asym~triques ou un sel pharmaceutiquement acceptable de ceux-ci. Le sel pharmaceutiquement acceptable peut Útre de formule (II).

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