Quinuclidine compounds as alpha-7 nicotinic acetylcholine...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/20 (2006.01) A61K 31/439 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2722325

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic .alpha. 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

L'invention porte sur des composés de formule I, comprenant leurs sels, ainsi que sur des compositions et des procédés d'utilisation des composés. Les composés sont des ligands pour le récepteur a-7 nicotinique et peuvent être utiles pour le traitement de divers troubles du système nerveux central, notamment des troubles affectifs et neurodégénératifs.

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