Quinuclidine derivative for treatment of inflammatory and...

Details Quinuclidine derivative for treatment of inflammatory and... Quinuclidine derivative for treatment of inflammatory and...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2149242

This invention relates to the quinuclidine derivative (2S,3S)-N-(5-n-propyl-2-methoxyphenyl)methyl-2-diphenylmethyl- 1-azabicyclo[2.2.2]octan-3-amine and its pharmaceutically acceptable salts. These compounds are substance P antagonists and are useful in the treatment of gastrointestinal disorders, inflamatory disorders, central nervous system disorders and pain.

L'invention porte sur un dérivé de la quinuclidine, soit la (2S,3S)-N-(5-n-propyl-2-méthoxyphényl)méthyl-2-diphénylméthyl- 1-azabicyclo¢2.2.2!octan-3-amine et ses sels acceptables en pharmacie. Ces composés sont des antagonistes de la substance P et sont utiles pour le traitement des troubles gastro-intestinaux, des inflammations, des troubles du système nerveux central et de la douleur.

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