Quinuclidine derivatives

Details Quinuclidine derivatives Quinuclidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 453/00 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07B 59/00 (2006.01) C07D 453/02 (2006.01) C07D 471/08 (2006.01) C07D 471/18 (2006.01) C07D 498/18 (2006.01) C07D 513/18 (2006.01)

Patent

CA 2086434

Quinuclidine derivatives of formulae (I), (II) or (III) and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R1, R2 and R3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in treating gas-trointestinal disorders, central nervous system disorders, inflammatory diseases, pain and migraine.

Dérivés de quinuclidine de formules (I), (II) ou (III) et leurs sels de qualité pharmaceutique, où m, P, Z, Y, R1, R2 et R3 correspondent aux définitions ci-dessous. Ces dérivés sont des antagonistes de la substance P et, par conséquent, utiles pour le traitement des troubles gastro-intestinaux, des troubles du système nerveux central, des maladies inflammatoires, de la douleur et de la migraine.

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