Quinuclidine derivatives and pharmaceutical compositions...

Details Quinuclidine derivatives and pharmaceutical compositions... Quinuclidine derivatives and pharmaceutical compositions...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 1/08 (2006.01) A61P 11/08 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2490082

Carbamates of formula (I) or pharmaceutically acceptable salts thereof, including quaternary ammonium salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as antagonists of M3 muscarinic receptors.

L'invention concerne des carbamates représentés par la formule (I), ou des sels pharmaceutiquement acceptables de ceux-ci, qui contiennent des sels d'ammonium quaternaires représentés par la formule (II). Par ailleurs, l'invention concerne des procédés de préparation de ces composés, des compositions pharmaceutiques contenant ces composés ainsi que l'utilisation thérapeutique de ces composés comme antagonistes des récepteurs muscariniques M3.

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