Quinuclidine derivatives and their use as muscarinic m3...

Details Quinuclidine derivatives and their use as muscarinic m3... Quinuclidine derivatives and their use as muscarinic m3...

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2583237

Compounds of Formula (I) ; in salt or zwitterionic form wherein R1, R2, R3 and R4 have the meanings as indicated in the specification, are useful for treating conditions that are mediated by the muscarinic M3 receptor, especially inflammatory or obstructive airways diseases. Pharmaceutical compositions that contain the compounds and a process for preparing the compounds are also described.

L'invention concerne des composés de formule (I), se présentant sous la forme d'un sel ou d'un zwittérion. Dans cette formule, R1, R2, R3 et R4 sont spécifiés dans la description, et sont utilisés pour traiter des états pathologiques médiés par le récepteur M3 muscarinique, en particulier les maladies inflammatoires et obstructives des voies respiratoires. L'invention concerne, de plus, des compositions pharmaceutiques qui contiennent les composés et un procédé pour préparer les composés.

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