Quinuclidinol derivatives as muscarinic receptor antagonists

Details Quinuclidinol derivatives as muscarinic receptor antagonists Quinuclidinol derivatives as muscarinic receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 453/02 (2006.01) A61K 31/439 (2006.01) A61P 11/12 (2006.01)

Patent

CA 2672446

The invention provides compounds of formula (I) wherein R5 is a group of formula (II) or (III) and R1, R2, R3, R4, R6, a, b, Z, Y and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation.

Cette invention concerne des composés représentés par la formule (I), dans cette formule, R5 représente un groupe représenté par la formule (II) ou par la formule (III) et R1, R2, R3, R4, R6, a, b, Z, Y et X sont tels que définis dans la spécification. Cette invention concerne également un procédé permettant leur préparation, des compositions pharmaceutiques contenant ces composés, un procédé permettant de préparer les compositions pharmaceutiques, leur utilisation à des fins thérapeutiques ainsi que des produits intermédiaires utilisés pour leur préparation.

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