R(+)-2-amino-3-hydroxypropanoic acid derivatives with...

Details R(+)-2-amino-3-hydroxypropanoic acid derivatives with... R(+)-2-amino-3-hydroxypropanoic acid derivatives with...

C - Chemistry, Metallurgy

07

C

C07C 229/22 (2006.01) A61K 31/197 (2006.01) A61K 31/198 (2006.01) C07C 237/12 (2006.01) C07C 251/24 (2006.01) C07C 271/22 (2006.01)

Patent

CA 2497347

The invention relates to the use of derivatives of <I>R</I>(+)-2-amino-3- hydroxypropanoic acid which is substituted on the azote by a group: (C1- C6)alkyl, (C3-C6)alkenyl, 3-oxo(C5-C6)alkyl, 3-oxo(C4-C6)alken-2-yl, phenyl(C1- C6)alkyl, phenyl(C2-C6)alkenyl, gem-diphenyl(C1-C6)alkyl, gem-diphenyl(C2- C6)alkenyl, (C1-C6)alkanoyl, optionally N-substituted alanyl, optionally N,N'- disubstituted lysinoyl, phenyl(C1-C6)alkylidene or gem-diphenyl(C1- C6)alkylidene, and the pharmaceutically-acceptable salts thereof for the preparation of medicaments that are intended for the treatment of diseases of the CNS due to reduced glycinergic transmission, such as for the treatment of autism, schizophrenia and Alzheimer's disease.

On décrit l'utilisation de dérivés de l'acide R(+)-2-amino-3-hydroxypropanoïque, substitué sur l'azote par un groupe (C¿1?-C¿6?)alkyle, (C¿3?-C¿6?)alcényle, 3-oxo(C¿5?-C¿6?)alkyle, 3-oxo(C¿4?-C¿6?)alcén-2-yle, phényl(C¿1?-C¿6?)alkyle, phényl(C¿2?-C¿6?)alcényle, gem-diphényl(C¿1?-C¿6?)alkyle, gem-diphényl(C¿2?-C¿6?)alcényle, (C¿1?-C¿6?)alcanoyle, alanyle éventuellement N-substitué, lysinoyle éventuellement N,N'-disubstitué, phényl(C¿1?-C¿6?)alkylydène ou gem-diphényl(C¿1?-C¿6?)alkylidène, et de leurs sels pharmaceutiquement acceptables pour la préparation de médicaments destinés au traitement de maladies du SNC dues à une transmission glycinergique réduite, notamment au traitement de l'autisme, de la schizophrénie et de la maladie d'Alzheimer.

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