(r)-4-(heteroaryl) phenylethyl derivatives and...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 37/00 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2702307

The present invention relates to a novel class of (R)-4-(heteroaryl) phenylpropionic derivatives of formula (I), useful in the inhibition of the chemotactic activation induced by the fraction C5a of complement. Said compounds are useful in the treatment of pathologies depending on the chemotactic activation of neutrophils and monocytes induced by the fraction C5a of the complement. In particular, the compounds of the invention are useful in the treatment of autoimmune hemolytic anemia (AIHA), psoriasis, bullous pemphigoid, rheumatoid arthritis, ulcerative colitis, acute respiratory distress syndrome, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of injury caused by ischemia and reperfusion.

La présente invention concerne une nouvelle classe de dérivés de (R)-4-(hétéroaryl)phénylpropioniques de formule (I), utiles pour inhiber l'activation chimiotactique induite par la fraction C5a du complément. Lesdits composés sont utiles dans le traitement de pathologies qui dépendent de l'activation chimiotactique des neutrophiles et des monocytes induite par la fraction C5a du complément. En particulier, les composés de l'invention sont utiles dans le traitement de l'hémolyse auto-immune (AIHA), du psoriasis, de la pemphigoïde bulleuse, de l'arthrite rhumatoïde, de la rectocolite hémorragique, du syndrome de détresse respiratoire aiguë, de la fibrose idiopathique, de la glomérulonéphrite et dans la prévention et le traitement de maladies causées par l'ischémie et la reperfusion.

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