C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2670595
(R) -5 -Methyl -4, 5-dihydro-pyrazole-1, 5 -dicarboxylic acid 1 - [ (4-chloro -phenyl) -amide] 5- {[2-f luoro-4- (2-oxo-2H-pyridin-1 -yl) -phenyl] -amide) pharmaceutical compositions, methods and methods of using the compound or pharmaceutical compositions thereof to treat diseases characterized by abnormal thrombosis in mammals. A crystalline form of (R) -5-Methyl-4, 5-dihydro-pyrazole-1, 5 -dicarboxylic acid 1-[(4- chloro- phenyl) -amide] 5- { [2-fluoro-4- (2-oxo-2H-pyridin-1 -yl) -phenyl] -amide} is also described. Formula (I):
L'invention concerne des compositions pharmaceutiques contenant du 1- [ ( 4 -chlorophényl) amide 5-{[2-fluoro-4- (2-oxo-2H-pyridin-1-yl) -phényl]amide) d'acide (R) -5-méthyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylique et des procédés associés, ainsi que des procédés d'utilisation de ces compositions ou du composé susmentionné destinés à traiter des maladies caractérisées par une thrombose anormale chez les mammifères. L'invention concerne également une forme cristalline de 1- [ ( 4 -chlorophényl) amide 5-{[2-fluoro-4- (2-oxo-2H-pyridin-1-yl) -phényl]amide) d'acide (R) -5-méthyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylique servant d'inhibiteur du facteur XA.
Edmunds Jeremy John
Samas Brian Matthew
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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