R-lansoprazole compositions and methods

Details R-lansoprazole compositions and methods R-lansoprazole compositions and methods

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/4439 (2006.01)

Patent

CA 2320963

Methods and compositions are disclosed utilizing optically pure (+) lansoprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of lansoprazole. The optically pure (+) isomer is also useful for the treatment of gastroesophageal reflux. (+) lansoprazole is an inhibitor of H+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.

La présente invention concerne des compositions et des procédés d'utilisation du (+)-lansoprazole optiquement pur permettant le traitement d'ulcères chez l'homme, tout en réduisant notablement le risque concomitant d'effets secondaires associés à l'utilisation du mélange racémique de lansoprazole. L'isomère (+) optiquement pur est aussi utile dans le traitement des reflux gastro-oesophagiens. Comme le (+)-lansoprazole est un inhibiteur de libération d'H?+¿, il permet de traiter d'autres troubles liés à l'hypersécrétion gastrique, tels que le syndrome de Zollinger-Ellison.

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