(r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium...

Details (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium... (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium...

C - Chemistry, Metallurgy

07

D

C07D 489/08 (2006.01) A61K 31/485 (2006.01) A61P 1/00 (2006.01) A61P 1/06 (2006.01)

Patent

CA 2670382

Novel (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs are disclosed. Pharmaceutical compositions containing the (R)-N-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs and methods for their pharmaceutical uses are also disclosed. Such analogs are disclosed as being useful in treating, among varying conditions, opioid-induced constipation.

La présente invention concerne de nouveaux (R)-N-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8. La présente invention concerne également des compositions pharmaceutiques contenant les (R)-N-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8 et leurs procédés d'utilisation pharmaceutique. De tels analogues sont décrits comme étant utiles dans le traitement, parmi des conditions variables, de la constipation induite par l'opioïde.

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