[r-(r*r*)]1-2-(4-fluorophenyl).beta.-.delta.-dihydroxy-5-...

Details [r-(r*r*)]1-2-(4-fluorophenyl).beta.-.delta.-dihydroxy-5-... [r-(r*r*)]1-2-(4-fluorophenyl).beta.-.delta.-dihydroxy-5-...

C - Chemistry, Metallurgy

07

D

167/233, 260/326

C07D 207/34 (2006.01) A61K 31/40 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2021546

[R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-((1- methylethyl)-3-phenyl-4-[(phenylamino)-carbonyl]-1H- pyrrole-1-heptanoic acid (formula I) or ( 2 R - t r a n s ) - 5 - ( 4 - f l u o r o p h e n y l ) - 2-(1-methylethyl-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy- 6-oxo-2H-pyran-2-yl)ethyl]-1H-pyrrole-3-carboxamide (formula II) and pharmaceutically acceptable salts thereof are useful for lowering cholesterol levels in mammals, including humans. The chemical structures of these compounds are depicted as follows: formula I Image formula II Image

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