C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/82 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2557426
Disclosed herein are methods of reducing infection of a cell by a pathogen, comprising decreasing activity of Rab9A or Rab11A in the cell, for example to treat or prevent a pathogen infection. Exemplary pathogens are those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.
L'invention concerne des procédés pour réduire l'infection d'une cellule par un pathogène, par exemple, pour traiter ou prévenir une infection par des pathogènes. Les pathogènes d'exemple comprennent ceux utilisant un radeau lipidique. La découverte concerne aussi des procédés pour identifier les agents impliqués dans l'infection par des pathogènes tels que les modulateurs de Rab9A et Rab11A.
Hodge Thomas W.
Mcdonald Natalie J.
Murray James L.
Rubin Donald
Sanchez Anthony
Smart & Biggar
The Govenment Of The United States Of America As Represented By Centers For Diseas
Vanderbilt University
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