Rabies recombinant adenovirus

Details Rabies recombinant adenovirus Rabies recombinant adenovirus

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/205 (2006.01) A61K 39/295 (2006.01)

Patent

CA 2234201

Described herein is a recombinant adenovirus adapted to raise in a mammal an immune response to rabies, the adenovirus having a functionally disrupted E1 region and comprising an expression cassette in which dna coding for rabies glycoprotein is linked operably with expression controls functional in a eukaryotic host.

Virus recombinant adapté pour susciter une réponse immunitaire vis-à-vis de la rage chez un mammifère, l'adénovirus ayant une région E1 dont la fonction a été modifiée et comportant une cassette d'expression dans laquelle l'ADN codant la glycoprotéine de la rage est liée fonctionnellement aux contrôles d'expression qui s'exercent dans un hôte eucaryote.

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