Rabies recombinant adenovirus

Details Rabies recombinant adenovirus Rabies recombinant adenovirus

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 31/70 (2006.01) A61K 39/205 (2006.01) A61K 48/00 (2006.01) C07K 14/145 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2233983

Described herein is a recombinant adenovirus adapted to raise in a mammal an immune response to rabies, the adenovirus having a functionally disrupted e1 region and comprising an expression cassette in which DNA coding for rabies glycoprotein is linked operably with expression controls functional in a eukaryotic host.

On décrit un adénovirus recombiné, conçu pour augmenter, chez un mammifère, une réponse immune à la rage, cet adénovirus présentant une région e1 interrompue fonctionnellement et comprenant une cassette d'expression dans laquelle l'ADN codant pour la glycoprotéine de la rage est lié de manière opérante à des commandes d'expression fonctionnelles chez un hôte eucaryote.

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