Rabies recombinant adenovirus

Details Rabies recombinant adenovirus Rabies recombinant adenovirus

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 31/70 (2006.01) A61K 39/205 (2006.01) A61K 48/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2246626

Described herein is a recombinant adenovirus adapted to raise in a mammal an immune response to rabies, the adenovirus having a functionally disrupted el region and comprising an expression cassette in which dna coding for rabies glycoprotein is linked operably with expression controls functional in a eukaryotic host.

Divulgation d'un adénovirus recombinant adapté pour induire chez un mammifère une réponse immunitaire à la rage, l'adénovirus ayant une région E1 dont le fonctionnement est perturbé et comprenant une cassette d'expression dans laquelle l'ADN codant pour la glycoprotéine de la rage est lié de façon à être utilisable à des contrôles d'expression fonctionnels dans un hôte eucaryote.

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