Raccoon poxvirus expressing rabies glycoproteins

Details Raccoon poxvirus expressing rabies glycoproteins Raccoon poxvirus expressing rabies glycoproteins

C - Chemistry, Metallurgy

12

N

C12N 15/863 (2006.01) A61K 39/205 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) A61P 31/14 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/47 (2006.01)

Patent

CA 2681454

The present invention relates to recombinant raccoon poxvirus vectors that express the rabies virus glycoprotein gene at the hemagglutinin (ha) locus of the poxvirus genome or express the glycoprotein gene of the same or different rabies strains at the thymidine kinase (tk) and the hemagglutinin (ha) loci of the poxvirus genome, and their use as adjuvant-free vaccines. The raccoon poxvirus vector comprises the nucleic acid molecules encoding the glycoprotein of a Challenge Virus Standard rabies strain inserted and expressed at the tk locus of the poxvirus genome and of a Pasteur-Paris rabies strain inserted and expressed at the ha locus of the poxvirus genome. The vaccine may optionally contain a mixture of additional feline and canine antigens for immunization of animals. Also disclosed are methods for inducing an immune response to rabies in a mammal by administering to the mammal an effective immunizing amount of the vaccine of the invention.

La présente invention concerne des vecteurs de poxvirus de raton laveur recombinants qui expriment le gène de glycoprotéine du virus de la rage au locus d'hémagglutinine (ha) du génome du poxvirus ou expriment le gène de glycoprotéine de la même souche de rage ou de souches différentes aux loci de la thymidine kinase (tk) et de l'hémagglutinine (ha) du génome du poxvirus, et leur utilisation en tant que vaccins sans adjuvant. Le vecteur de poxvirus de raton laveur comprend les molécules d'acide nucléique codant la glycoprotéine d'une souche de rage Challenge Virus Standard insérées et exprimées au locus tk du génome de poxvirus et celles d'une souche de rage Pasteur-Paris insérées et exprimées au locus ha du génome de poxvirus. Le vaccin peut contenir en option un mélange d'antigènes félins et canins supplémentaires pour l'immunisation d'animaux. Elle concerne également des procédés pour induire une réponse immunitaire contre la rage dans un mammifère en administrant au mammifère une quantité immunisante efficace du vaccin de l'invention.

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