Racemisation of precursors to levobupivacaine and analogues...

Details Racemisation of precursors to levobupivacaine and analogues... Racemisation of precursors to levobupivacaine and analogues...

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) C07B 55/00 (2006.01) C07C 231/24 (2006.01) C07C 233/47 (2006.01)

Patent

CA 2201780

A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture or a mixture enriched in the opposite enantiomer from that desired, with the optically-active acid in a solvent comprising an acid that causes racemisation, in the absence of aldehyde.

Procédé de préparation d'acide pipécolinique optiquement enrichi en sel avec un acide optiquement actif, qui consiste à transformer de manière asymétrique de l'acide pipécolinique, en tant que mélange racémique ou de mélange enrichi dans l'énantiomère opposé à celui désiré, avec l'acide optiquement actif dans un solvant comprenant un acide qui provoque la racémisation, en l'absence d'aldéhyde.

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