Radiation cross-linked hydrogels

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/74 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 31/765 (2006.01) A61K 47/30 (2006.01) A61L 24/00 (2006.01) A61L 24/04 (2006.01) A61L 26/00 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/52 (2006.01) A61L 27/58 (2006.01) A61L 31/06 (2006.01) A61L 31/14 (2006.01) C08J 3/28 (2006.01) C08L 71/02 (2006.01)

Patent

CA 2437870

Radiation-crosslinked, biodegradable, synthetic hydrogels and their use in various applications, including certain medical applications wherein the hydrogel(s) are implanted on or in the body of a human or animal patient. Radiation-crosslinked, biodegradable, synthetic hydrogels of this invention may be prepared by irradiating monomers (e.g., ethylenically unsaturated hydrocarbons such as acrylic monomers and methacrylic monomers) or polymers, some of which are biodegradable or which contain biodegradable units or subunits. Specific medical applications of these radiation-crosslinked, biodegradable, synthetic hydrogels include applications wherein the hydrogel is used for hemostasis, tissue augmentation, tissue engineering, embolization, closure of vascular punctures or wounds and other medical applications.

L'invention concerne des hydrogels synthétiques, biodégradables, réticulés par rayonnements, et leur utilisation dans diverses applications, y compris certaines applications médicales, au cours desquelles les hydrogels sont implantés sur le corps d'un patient humain ou animal ou dans ledit corps. On peut préparer lesdits hydrogels en irradiant des monomères (par exemple, des hydrocarbures non saturés, tels que des monomères acryliques et des monomères méthacryliques) ou des polymères, dont certains sont biodégradables ou contiennent des unités ou des sous-unités biodégradables. Les applications médicales de ces hydrogels synthétiques, biodégradables, réticulés par rayonnements comprennent des applications impliquant l'utilisation de l'hydrogel en cas d'hémostase, d'augmentation cellulaire, d'ingénierie tissulaire, d'embolisation, d'occlusion de ponctions vasculaires ou de blessures, et d'autres applications.

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