Radiation dosimetry and blocking antibodies and methods and...

Details Radiation dosimetry and blocking antibodies and methods and... Radiation dosimetry and blocking antibodies and methods and...

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 39/395 (2006.01) G01T 1/161 (2006.01)

Patent

CA 2587172

Disclosed is a method for dosimetry estimation for a region of interest at or around a surgically created resection cavity in a subject. These methods enable medical practitioners to estimate the amount of administered Radioimmunotherapy (RIT) agent needed to safely and effectively achieve a final Radiation Absorbed Dose (RAD). Furthermore, computer hardware and software are provided herein, so that the methods according to the invention may be automated for more efficient use. Also disclosed is a method of enhancing delivery of therapeutic antibodies that specifically bind to an extracellular stromal constituent of a tumor in a mammalian subject. The method comprises administering to a subject an effective dosage of a blocking antibody, said blocking antibodies specifically binding to said extracellular stromal constituent and blocking the binding of therapeutic antibodies to non- target tissue.

L'invention concerne un procédé d'estimation de dosimétrie pour une région d'intérêt au niveau d'une cavité de résection créée de façon chirurgicale chez un sujet. Ces méthode permettent aux cliniciens d'estimer le taux d'agents de radioimmunothérapie administrés (RIT) requis afin de produire sûrement et efficacement une dose absorbée finale de rayonnement (RAD). L'invention concerne également un matériel et un logiciel informatique, de sorte que les procédés selon l'invention peuvent être automatisés pour une utilisation plus efficace. L'invention concerne également un procédé permettant d'améliorer la distribution d'anticorps thérapeutiques qui se lient spécifiquement à un constituant stromal extracellulaire d'une tumeur chez un mammifère. Cette méthode consiste à administrer à un sujet une dose efficace d'un anticorps bloquant, lequel se lie spécifiquement audit constituant stromal extracellulaire et bloque la liaison d'anticorps thérapeutiques à un tissu non cible.

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