C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2438129
Compositions and methods for increasing the fluorescence intensity of molecules are provided. In particular, compositions and methods directed to increasing the intrinsic fluorescence of biomolecules and low quantum yield fluorophores are described. The intrinsic florescence of biomolecules is increased by positioning a metal particle and a biomolecule at a distance apart sufficient to increase the radiative decay rate of the biomolecule. Methods for the identification of nucleic acids are also provided. The compositions and methods can also be used to increase the emission of any fluorophore, such as the extrinsic probes used to label biomolecules.
L'invention concerne des compositions et des procédés permettant d'augmenter l'intensité de fluorescence de molécules. L'invention concerne plus particulièrement des compositions et des procédés destinés à augmenter la fluorescence intrinsèque de biomolécules et de fluorophores à faible rendement quantique. On augmente la fluorescence intrinsèque de biomolécules en plaçant une particule métallique et une biomolécule à une distance suffisante pour augmenter son taux de décroissance radiative. L'invention concerne également des procédés d'identification d'acides nucléiques. Les compositions et les procédés peuvent être utilisés pour augmenter l'émission d'un fluorophore, tel que les sondes extrinsèques utilisées pour marquer des biomolécules.
Gowling Lafleur Henderson Llp
University Of Maryland Baltimore
LandOfFree
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