A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01)
Patent
CA 2509328
A method for achieving hemolymphopoietic chimerism is disclosed. The method involves the steps of administering to a recipient a bone seeking radiopharmaceutical; transplanting bone marrow-derived cells into the recipient; and transiently suppressing lymphocyte response so as to induce hemolymphopoietic chimerism. The method is useful for decreasing rejection of transplanted organs, tissues or cells and for treating autoimmune diseases. The present invention has the advantage of inducing hemolymphopoietic chimerism without the need for external radiation or harsh cytotoxic drugs. The present invention has the additional advantage of significantly prolonging tolerance to an organ, cell, or tissue transplant.
L'invention concerne une méthode permettant d'obtenir un chimérisme hémolymphopoïétique. Ladite méthode consiste à administrer à un receveur un pharmaceutique ostéotrope ; à greffer des cellules issues de la moelle osseuse chez le receveur ; et à supprimer la réponse lymphocytaire de manière transitoire afin d'induire un chimérisme hémolymphopoïétique. Ladite méthode est utile pour diminuer le rejet d'organes, de tissus ou de cellules greffés ou pour traiter des maladies auto-immunes. La présente invention présente l'avantage d'induire un chimérisme hémolymphopoïétique sans recourir à l'irradiation externe ou à des médicaments cytotoxiques durs. La présente invention présente l'avantage supplémentaire de prolonger de manière significative la tolérance d'une greffe d'organe, de cellule ou de tissu.
Inverardi Luca A.
Paganelli Giovanni
Ricordi Camillo
Serafini Aldo N.
Simon Jaime
Smart & Biggar
University Of Miami
LandOfFree
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