Radioactive arsenic-containing compounds and their uses in...

A - Human Necessities – 61 – K

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A61K 51/00 (2006.01) A61K 33/36 (2006.01) A61K 41/00 (2006.01) A61K 51/02 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2461243

This invention provides a process for producing a radioactive arsenic-containing compound, comprising the steps of: (i) subjecting an arsenic-containing compound to a neutron irradiation treatment, said arsenic-containing compound being selected from a group consisting of As2O3, As2S3, As2S2, and a combination thereof, such that the arsenic element contained in the arsenic-containing compound is converted to a radioactive arsenic isotope; and (ii) recovering the resultant product from step (i). This invention also provides a pharmaceutical composition comprising a therapeutically effective amount of the radioactive arsenic-containing compound and a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the treatment of tumors/cancers such as hematological malignancies and solid tumor.

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