C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
260/212, 260/570
C08B 37/02 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C08B 31/00 (2006.01)
Patent
CA 1252087
-1- Abstract: The invention provides a radioactive diagnostic agent which comprises (1) a unit of a polyformyl compound having at least three formyl groups per molecule, (2) at least two units of an amino group-containing chelating compound bonded to the polyformyl compound via a methyl- eneimine linkage (-CH=N-) or a methyleneamine linkage (-CH2NH-) formed by the condensation between a formyl group in the polyformyl compound and the amino group in the chelating compound, optionally followed by reduction, (3) at least one unit of an amino group-containing phys- iologically active substance bonded to the polyformyl compound via a methyleneimine linkage or a methyleneamine linkage formed by the condensation between a formyl group in the polyformyl compound and the amino group in the physiologically active substance, optionally followed by reduction, and (4) at least two radioactive metallic elements of which each is bonded to the chelating compound through a chelating bond. The diagnostic agent can be used for non-invading nuclear medical diagnosis.
442833
Hazue Masaaki
Takahashi Keietsu
Uedo Nobuo
Kirby Eades Gale Baker
Nihon Medi-Physics Co. Ltd.
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