Radioactive gold nanoparticles and methods of making and...

Details Radioactive gold nanoparticles and methods of making and... Radioactive gold nanoparticles and methods of making and...

B - Operations, Transporting

22

F

B22F 9/02 (2006.01) B22F 9/24 (2006.01)

Patent

CA 2743315

Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing a solution comprising gold (Au- 197) ions; and b) exposing the solution to neutron irradiation to generate a composition comprising non-ionic R-GNPs. Alternatively, the method comprises: a) providing a solution that comprises a composition comprising gold (Au-197) nanoparticles (GNPs); and b) exposing the GNP solution to neutron irradiation to generate a composition comprising non-ionic R-GNPs. Compositions that comprises non-ionic R-GNPs encapsulated within and/or anchored to MSNs, and methods of making the same are also disclosed.

L'invention porte sur des procédés de préparation d'une composition qui comporte des nanoparticules d'or radioactives non ioniques (R-GNP). Le procédé comporte : a) l'utilisation d'une solution comportant des ions or (Au-197), et b) l'exposition de la solution à une irradiation par des neutrons pour générer une composition comportant des nanoparticules d'or radioactives non ioniques. En variante, le procédé comporte : a) l'utilisation d'une solution qui comporte une composition comportant des nanoparticules d'or (Au-197) (GNP), et b) l'exposition de la solution de nanoparticules d'or à une irradiation par des neutrons pour générer une composition comportant des nanoparticules d'or radioactives non ioniques. L'invention porte également sur des compositions qui comportent des nanoparticules d'or radioactives non ioniques encapsulées à l'intérieur de nanoparticules de silice mésoporeuse (MSN) et/ou ancrées sur celles-ci, et sur des procédés de préparation de celles-ci.

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